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However, in this case, the patients usually do not show symptoms of metabolic acidosis or hemolytic anemia, and antioxidant therapies are ineffective ( Table 2 Clinical features and laboratory data corresponding to patients diagnosed with GSSD in China

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The role of R-2-HG as an oncometabolite has been implicated in epigenetic modifications through the inhibition of -KG-dependent dioxygenases and demethylases, which has been assumed to be a driver of tumorigenesis 117,118

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